Publications
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Development of a process map : a step towards a regime map for steady-state high shear wet twin screw granulation Ghent University
Improved process and formulation understanding during continuous twin screw wet granulation and downstream processing Ghent University
Formulation design for continuous twin screw wet granulation Ghent University
Investigation of twin screw granulation : integrating experimental and computational approaches Ghent University
Continuous twin screw granulation: influence of process variables on granule and tablet quality Ghent University
Experimental and model-based investigation of twin screw granulation: towards more profound process knowledge Ghent University
Blend uniformity evaluation during continuous mixing in a twin screw granulator by in-line NIR using a moving F-test Ghent University
Identification of continuous twin-screw melt granulation mechanisms for different screw configurations, process settings and formulation Ghent University
Twin-screw melt granulation (TSMG) is a promising continuous manufacturing technology for the processing of high drug load formulations and to formulate heat- and moisture-sensitive active pharmaceutical ingredients (APIs). This study evaluates the influence of process parameters for TSMG, mainly focusing on the effect of the screw configuration combined with screw speed, throughput and barrel temperature, to elucidate the melt granulation ...