Projects
NextEboVax: Next generation vaccines for outbreak prepardness KU Leuven
The family Filoviridae consists of antigenically distinct human pathogenic viruses such as, among others, Ebola virus, Marburg virus and Sudan virus. Filoviruses have evolved sophisticated ways of evading the immune response thereby causing high mortality rates, and outbreaks are recurring over the past decades. Only two vaccines have been granted market authorization by the European Medicines Agency (EMA) for Ebola virus, yet none for the ...
Rapid ex-vivo detection, quantification and characterisation of cell-mediated immune responses induced by natural infection or vaccination with SARS-CoV-2 orr other pathogens. Ghent University
Development of a rapid, sensitive, and reproducible method for the ex-vivo detection, quantification and characterization of cell-mediated immune responses induced by natural infection or vaccination. This method will hopefully enable us to replace the applied laborious and expensive methodologies thereby increasing the applicability of these types of immune monitoring methods in large (field) trials. This simplified method will allow for ...
PBMC service laboratory. University of Antwerp
Valorization of novel strategies for the prevention of viral infection and inhibition of viral replication. KU Leuven
Antiviral drugs are only available for a handful of viruses. Also in the vaccine field a similar scenario can be seen. For many other viral infections that pose an important treat to human health (including re-emerging & neglected infections), there are no antiviral strategies available. The changing ecosystem increases the pressure on the appearance of (novel) viruses (with epidemic/pandemic potential). With this project, we aim to ...
Research on the containment of antibiotic resistance and the immune response of prophylactic and therapeutic vaccines. University of Antwerp
Predicting Immune responses by Modeling immunoSequencing data (PIMS). University of Antwerp
Assessing the Crucial Role of IgMs Against the Parasitosis of Salivarian Trypanosomes Ghent University
Salivarian trypanosomes are single-celled extracellular parasites that reside in the blood, lymphatics, and various tissues. They cause infections in humans, livestock, and game animals. Trypanosomes thrive in plain sight of the immune system, by deploying multiple evolutionary acquired evasion strategies, which aim at avoiding antibody-mediated destruction as much as possible. Interestingly, assessing experimental infections has shown that ...
Collection of serum in former participants of vaccine studies related to Salmonella for the support of further research to Salmonella-related diseases. University of Antwerp
A platform for the fast development of thermostable lyophilized mRNA lipid nanoparticle (LNP) vaccines Ghent University
Within this project an innovative spinfreeze technology will be used to enhance the thermostability of mRNA vaccines. An analytical toolbox will be developed to analyse and understand the impact of the freeze drying process on the mRNA vaccines.