Projects
Development and use of relevant hamster and mouse SARS-COV-2 infection models to aid in the design of therapeutic and prophylactic options for COVID-19 Ghent University
In some patients, COVID-19 progresses from an initially mild viral syndrome to a severe and life-threatening multi-system disorder with cytokine storm. This coronavirus pandemic is putting healthcare systems worldwide under unprecedented and increasing pressure. Efficient vaccines as well antiviral (small molecules and biologicals) and anti-inflammatory drugs are urgently needed. Given the emergency, the repurposing of small molecules and/or ...
Measuring vaccination coverage in Flanders University of Antwerp
Robust, user-friendly and state-of-the-art fluorescence activated cell sorter (FACS) Ghent University
Fluorescence-activated cell sorting (FACS) allows for isolation of individual cells and pathogens from complex cell mixtures derived e.g. from body fluids and tissues based on different cell characteristics (size, granularity and fluorescence). Isolated cells can be characterized in molecular detail, either directly or upon further cultivation. As such, FACS represents an essential tool in a plethora of life science research domains, ...
Investigation of the role of regulatory T cells during acute dengue virus infection Hasselt University
Applying bioinformatics in dendritic cell-mediated immune cell activation research: automated analysis of high-dimensional flow cytometry datasets. University of Antwerp
In vivo proof-of-concept for the efficacy of YF/HBc, a novel therapeutic hepatitis B vaccine candidate KU Leuven
Development of a novel nanoparticle formulation for mRNA based therapeutic vaccination Vrije Universiteit Brussel
of RNA to ambient RNases, these approaches will however require protection of mRNA.
So far, therapeutic ...
Development of a robust expression system for stable soluble influenza neuraminidase Ghent University
Influenza, also called the flu, is an important infectious disease caused by influenza A and B viruses. Vaccines are available that can prevent or reduce influenza symptoms. However, these vaccines provide limited protection primarily due to mismatch between the vaccine components and circulating virus. Interestingly, it has been shown that experimental vaccines based on NA can provide protection in animal models of influenza. Further, ...