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Can the body slope of interference screw affect initial stability of reconstructed anterior cruciate ligament?: An in-vitro investigation KU Leuven
BACKGROUND: Superior biomechanical performance of tapered interference screws, compared with non-tapered screws, with reference to the anterior cruciate ligament (ACL) reconstruction process, has been reported in the literature. However, the effect of tapered interference screw's body slope on the initial stability of ACL is poorly understood. Thus, the main goal of this study was to investigate the effect of the interference screw's body slope ...
Shedding a light on the physical stability of suspensions micronised with intensified vibratory milling; A trend observed with decreasing particle size as a function of time KU Leuven
Intensified vibratory milling is a nanonisation and micronisation technology which can be used to enable the oral bioavailability of poorly soluble compounds. The generated nano- and microsuspensions entail a large surface area which enhances the compounds dissolution rate, yet this large surface area is thermodynamically unfavourable and hence spontaneous destabilisation may occur, i.e. physical instability. Stability studies on suspensions ...
Determinants of inequalities in years with disability Vrije Universiteit Brussel
BACKGROUND: Persons with a lower socioeconomic position spend more years with disability, despite their shorter life expectancy, but it is unknown what the important determinants are. This study aimed to quantify the contribution to educational inequalities in years with disability of eight risk factors: father's manual occupation, low income, few social contacts, smoking, high alcohol consumption, high body-weight, low physical exercise and ...
24-hour blood pressure variability and treatment effect of intravenous alteplase in acute ischaemic stroke KU Leuven
INTRODUCTION: To assess the association between 24 h blood pressure variability (BPV) on functional outcome and treatment effect of intravenous alteplase in acute ischaemic stroke. PATIENTS AND METHODS: In all patients with acute ischaemic stroke of unknown onset randomised in the WAKE-UP (Efficacy and Safety of magnetic resonance imaging [MRI]-based Thrombolysis in Wake-Up Stroke) trial, blood pressure (BP) was measured before randomisation and ...
Functional dissection of regulatory T cell plasticity and stability KU Leuven
Treg are crucial players in creating immune tolerance and maintaining immune homeostasis. Malfunction or insufficient numbers of Treg have been associated with diverse conditions, ranging from atopic disease, such as allergic asthma to autoimmune diseases. Treg are characterized by expression of the transcription factor Foxp3, which is essential for establishing and maintaining their suppressive transcriptional program. The importance of this ...