A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cells KU Leuven
Ionized calcium (Ca2+) is the most versatile cellular messenger used by cells. Virtually all cells in the human body employ Ca2+ signals, i.e. rapid changes in intracellular Ca2+ concentration, to control cell physiological functions in response to extrinsic and intrinsic stimuli. Perturbations in Ca2+ homeostasis & dynamics vitiate physiological processes, acting as early drivers of disease progression and pathological outcomes. Hence, ...