Publications
Simultaneously estimating evolutionary history and repeated traits phylogenetic signal: applications to viral and host phenotypic evolution KU Leuven
A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver Ghent University
Equine herpesvirus type 1 enhances viral replication in CD172aU+207A monocytic cells upon adhesion to endothelial cells Ghent University
Viral transmission dynamics at single-cell resolution reveal transiently immune subpopulations caused by a carrier state association KU Leuven
Initial suboptimal CD4 reconstitution with antiretroviral therapy despite full viral suppression in a cohort of HIV-infected patients in Senegal Institute of Tropical Medicine
OBJECTIVE: We determined the risk factors and incidence of clinical events associated with suboptimal immune reconstitution (SIR) defined by an increase in CD4 inferior to 50 cells/μL, from inclusion up to six months of antiretroviral treatment (ARVT), in patients with an undetectable viral load (<50 copies/mL).
METHODS: Logistic regression and Cox's proportional hazards model were used to examine risk factors for SIR and the ...
Oral fluid as a detection tool for viral infections University of Antwerp
Drug resistance and plasma viral RNA level after ineffective use of oral pre-exposure prophylaxis in women Institute of Tropical Medicine
BACKGROUND: Pre-exposure prophylaxis (PrEP) with daily oral emtricitabine (FTC)/tenofovir disoproxil fumarate may select for drug resistance if there is low adherence.
METHODS: Plasma viral HIV-1 RNA level, CD4+ T-cell counts, and drug resistance were evaluated among seroconverting women in the FEM-PrEP trial (clinicaltrials.gov NCT00625404) using standard clinical tests, allele-specific PCR (ASPCR), and by deep sequencing. Tenofovir, ...