The search for toxin-derived modulators of voltage-gated sodium channels and their in vivo effects in autoimmune encephalomyelitis KU Leuven
Voltage-gated sodium channels (Navs) are key players in the generation and propagation of electrical signals in the human body. They are found in the membrane of electro-excitable cells and underlie the event of action potentials. Due to their crucial role in excitability, malfunctioning of these channels inevitably leads to severe physiological disorders. Therefore, defect Navs are associated with diseases like epilepsy and the long QT ...