Projects

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The role of adipose tissue hypoxia in obesity and obstructive sleep apnea. University of Antwerp

Annelies Van Eyck
Laboratory Experimental Medicine and Pediatrics (LEMP)
Obesity and the metabolic syndrome are highly prevalent in children, adolescents and adults. It is known that the components of the metabolic syndrome track from childhood to adolescence and adulthood implicating an earlier onset of cardiovascular morbidity. This stresses the importance of early prevention and management of obesity. Unfortunately, the medical management of obesity remains challenging. It is therefore important to study certain ...

Adipose tissue expandability and dysfunction: modulator of liver damage and disease progression in NAFLD? University of Antwerp

Luisa Vonghia
Laboratory Experimental Medicine and Pediatrics (LEMP)
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in the Western world, affecting about 20-30% of the population. The hallmark of NAFLD is fat accumulation in the hepatocytes (steatosis), which is not triggered by well-established causes of steatosis like alcohol or hepatotoxic substances. The concomitant presence of inflammation and degenerative injury of hepatocytes is labelled non-alcoholic ...

ADIPINJECT: Development for injectable temperature-responsive hydrogels for adipose tissue engineering Ghent University

Peter Dubruel
Department of Organic and Macromolecular Chemistry

Injectable solutions for adipose tissue engineering have recently gained increasing attention among others by lipofilling procedures, breast constructions, wound treatment, ... With the aim to meet an urgenet need in the medical field, the present project aims at developing biomimetic, injectable temperature-responsive hydrogel building blocks suitable for adipose tissue regeneration. Biocompatible hydrogel building will be developed and be ...

The role of the adipose tissue in the pathogenesis of insulin resistance and increased disease susceptibility in high yielding dairy cows Ghent University

Geert Opsomer
Department of Internal Medicine, Reproduction and Population Medicine

Obesity around the moment of calving increases the risk to develop metabolic, infectious and reproductive diseases in high yielding dairy cows. In this project, the role of the adipose tissue in the parthogenesis of these diseases, will be examined macroscopically, microscopically and molecularly.

Elucidating mechanisms of insulin resistance in adipose tissue KU Leuven

Mitsugu Shimobayashi
Clinical and Experimental Endocrinology
Jaarlijks sterven minstens 2.8 miljoen mensen aan de gevolgen van obesitas. Vijftig procent van de Belgische bevolking heeft overgewicht of obesitas, en 1 op 12 volwassen Belgen heeft diabetes, die voor 80% toe te schrijven is aan overgewicht Daarom is er dringend nood aan beter inzicht in de ontstaansmechanismen van obesitas-gerelateerde diabetes en aan meer effectieve behandelingen. Obesitas ontstaat ten gevolge van een aanhoudende positieve ...

Adipose tissue-resident Th cells modulate the adipose tissue-brain axis in multiple sclerosis Hasselt University

Bieke BROUX
Immunology & Infection, Maastricht University
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disorder of the brain. One known risk factor for developing MS is obesity. This common health condition leads to a chronic inflammatory state in adipose tissue (AT). However, the link between obese AT and MS remains elusive, but inflammatory processes in AT are likely to be involved. I hypothesize that AT-resident T helper (Th) cells, mediate the increased obesity-related MS ...

Regucyte : Bringing Regenerative Medicine to the Clinic Ghent University

An Van Den Bulcke
Department of Diagnostic Sciences, Department of Basic and Applied Medical Sciences, Department of Human Structure and Repair, Department of Organic and Macromolecular Chemistry

Adipose tissue and its byproducts are often used in the operating room (OR). Adipose tissue is transplanted in the same patient to treat surgical defects. Byproducts such as stromal vascular fraction (SVF) are used in regenerative medicine. When working with adipose tissue, an ischemia time of less than 6h is respected. Afterwards adipose tissue and its byproducts suffer cell death. We discovered a new technology to prolong the survival of ...

Onderzoek naar een evolutionair bewaard mechanisme van suikerdetectie en de novo lipogenese?. KU Leuven

Mitsugu Shimobayashi
Clinical and Experimental Endocrinology
Animals sense and adapt to fluctuating nutrient supplies to maintain metabolic homeostasis. In a sufficiently fed condition, organisms activate the signaling pathways and transcriptional programs to promote the storage of the excess energy, which is leveraged to sustain basal activities in a food-deprived state. In vertebrates, adipose tissue serves as the primary energy storage organ. In addition to acting as a reservoir for dietary lipids, ...

The role of regulatory T cells and Th1/Th17/Th22 cells in the pathogenesis of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic SteatoHepatitis in mice and humans. University of Antwerp

Sven Francque
Laboratory Experimental Medicine and Pediatrics (LEMP)
Non-Alcoholic Fatty Liver Disease (NAFLD) is a chronic liver disease defined by the accumulation of fat in the hepatocytes. In case of additional inflammation and signs of hepatocyte degeneration the disease is called Non-Alcoholic SteatoHepatitis (NASH), which represents a more severe disease subtype. Given the clear correlation between NAFLD and obesity and diabetes, and the increasing incidence of the latter two, NAFLD constitutes a major ...

FAT-metBC: Facing increased Adiposity in Treating metastatic Breast Cancer KU Leuven

Christine Desmedt
Laboratory for Translational Breast Cancer Research, Semmelweis Egyetem
In industrialized countries, approximately 1 out 8 women will develop breast cancer (BC) in her lifetime and 1 out of 2 is overweight or obese. While heavier BC patients are at higher risk of recurrence and death, BC is so far still treated independently of the patient’s adiposity because of the limited knowledge accumulated so far, specifically at the metastatic level. Autopsy programs represent a unique opportunity for research since they ...