Projects
Targeting CD70-positive cancer-associated fibroblasts to improve chemotherapy and alleviate the immuno-suppressive tumor microenvironment in advanced colorectal cancer. University of Antwerp
A phase I dose-escalation study to determine the maximum tolerated dose of radiotherapy, in combination with concomitant 5-FU chemptherapy, in patients with locally advanced rectal cancer with a positive circumferential resection margin (cCRM). KU Leuven
Combined chemotherapy and inflammasome neutralization for the treatment of non-small cell lung carcinoma Ghent University
Chemoresistance of non-small-cell lung carcinoma (NSCLC) cells underlies the poor prognosis of patients with advanced disease. Hence, it seems plausible to combine the standard-of-care chemotherapy for NSCLC (typically a combination of platinum-based compounds and taxanes) with strategies that block the induction of chemoresistance.
Recent evidence illustrated that tumor-associated macrophages contribute to diminished therapy ...
Unravelling the synergistic potential of CD70directed CAR natural killer cells with firstline chemotherapy in 3D culture models as a novel combination treatment for metastatic colorectal cancer patients. University of Antwerp
Impact of vaginal morbidity on sexual functioning in cervical cancer patients treated with neo-adjuvant chemotherapy followed by surgery. Ghent University
In Belgium, 600 women are yearly diagnosed with cervical cancer
(CX), with a peak around 45 years (sexually active at the time of
diagnosis). Treatment of limited CX consists of surgery, completed
by chemo-radiotherapy (C-RT) in case of high-risk of relapse.
Inoperable, locally advanced tumors are treated by C-RT and
brachytherapy. The 3-year local control is 73% to 94%. To increase
this, we have been ...
Unravelling EMT-controlled aetiology and chemotherapy resistance of ovarian carcinosarcoma Ghent University
Ovarian carcinosarcoma (OCS) is the most aggressive histological subtype of ovarian cancer. Its poor prognosis is mainly due to diagnosis at a late, advanced stage and chemotherapy resistant relapses. In this project, we seek to unravel the complex nature of this biphasic cancer consisting of both epithelial/ carcinoma and mesenchymal/sarcoma components. Epithelial-mesenchymal transition is considered the crucial process for the ...