Paving the way to precision medicine in childhood-onset diseases: A lifespan perspective on accelerated aging using the epigenetic clock Ghent University
Many childhood-onset diseases used to be lethal. Improved life expectancy yield that most patients can survive into adulthood, to date. However, survivors of childhood-onset diseases often develop morbidities that suggest accelerated aging. Congenital heart disease is a typical example of a childhood-onset disease. It is the most common birth defect, comprising a spectrum of mild, moderate and complex heart defects. Several age-related ...