Coaxial electrospraying to produce coated amorphous solid dispersion particles: from polymer solution to fixed dose combinations KU Leuven
During the past decades, the amount of active pharmaceutical ingredients (APIs) with low aqueous solubility and dissolution rate and hence low oral bioavailability has been growing firmly. To address this problem, amorphous solid dispersions (ASDs) can be formulated in which the API is mixed at a molecular level into an inert amorphous polymer. Due to the amorphous nature of these formulations, both solubility and dissolution rate can be ...