Investigation of bead coating as manufacturing process for the development of amorphous solid dispersions. KU Leuven
The number of drug molecules that show poor aqueous solubility and low dissolution rate has significantly increased during the past two decades, resulting in low oral bioavailability. Among the different formulation strategies that are being studied and applied to overcome this solubility issue, the dispersion of a poorly soluble drug in an inert polymer matrix to form amorphous solid dispersions (ASDs) is a very promising one. Spray drying ...