Understanding DNA GyraseB ATPase inhibition in the light of structure and ligand-based modelling techniques. KU Leuven
The alarming antibiotic resistance spread is the main reason
that demands the continued investigation to search for new antimicrobial
agents. DNA Gyrase is a validated antibacterial target that can be used for
this purpose. This essential prokaryotic type II topoisomerase enzyme is
involved in DNA replication, transcription and recombination by introducing
negative supercoiling ...