Projects
High-Speed, High-Resolution CMOS Analog-to-Digital Converters KU Leuven
The continuous need for higher data rates and low power dissipation for next-generation communication standards calls for innovation in the design of extremely high-speed analog-to-digital converters (ADCs), exceeding 10 GS/s, while maintaining a medium-to-high resolution. Although complex time interleaving ADCs are a partial solution for this demand, the ADC analog front-end remains a speed bottleneck under power constraints. Moreover, even ...
Synthesis and biological evaluation of C-nucleoside analogues KU Leuven
C-Nucleosides are an important family of compounds with promising biological activities. In C-nucleosides, the labile C-N glycosidic linkage of classical N-nucleosides is replaced by a more stable C-C bond, which makes C-nucleosides resistant against hydrolysis. Some naturally occurring C-nucleosides such as formycin and showdomycin are potent antibiotics, while pseudouridine, an isomer of uridine, is able to stabilize RNA duplexes by ...
Development of Artificial Genetic Systems for Therapeutic Applications KU Leuven
Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are among the most remarkable biomolecules occurring in nature, since they store and transfer all genetic information using only four letters (G, C, A & T or U). In the last 60 years, since the discovery of the structure of nucleic acids, numerous chemically modified nucleosides and nucleotides have been produced and incorporated into oligomeric sequences either by chemical or ...
Synthesis, conformational study and biological evaluation of pentopyranoside nucleoside phosphonates KU Leuven
Synthetic analogues of nucleosides, nucleotides and oligonucleotides have found application in the life-saving treatment of cancers and viral infections. High-affinity binding oligonucleotides have potential in the development of antisense, siRNA, aptamer and xeno nucleic acids (XNAs) research. These synthetic mimics usually carry modifications of either one or more of the essential components of the nucleic acid, such as nucleobase, sugar ...
Nantenna and Schottky diode based monolithic optical receivers KU Leuven
Fibreoptic networks are the driving system behind increasing data-rates. Optical communication has promising prospects, is continuously evolving and is the choice for integration in future infrastructures. However, such networks are costly to implement due to the laser and photodetector components that are needed to convert the optical and electrical signals to each other. These external components are currently developed through less common ...
Rheological and Microstructural Investigation of Capillary Suspensions under Shear KU Leuven
The addition of small amounts of an immiscible secondary fluid to a suspension can lead to particle bridging and network formation. This is caused by the attractive capillary force due to liquid bridges formed between the particles. Thus, this kind of suspensions is called a ``capillary suspension''. The capillary bridging phenomenon can be used to stabilize particle suspensions and precisely tune their rheological properties. Capillary ...