Tissue specific modulation of the effects of glucocorticoids by androgens and the androgen receptor: revealing the mechanisms of cross tal KU Leuven
Androgens and glucocorticoids are steroid hormones with very different roles in (patho-)physiology. While androgens are known as the male steroids with anabolic effects, glucocorticoids are catabolic hormones with a key role in metabolic processes that govern whole-body energy metabolism. Clinically, long term use of androgens results in increased bone and muscle formation, while glucocorticoids induce osteoporosis and muscle loss. By ...