Projects
Influence of sex steroids on bone mineralization and maturation, (pre)pubertal growth and body composition in late childhood and adolescence in males. Ghent University
Besides the influence of the individual sex steroid levels we want to investigate the influence of the estrogen/androgen ratio in determining the tempo of bone mineralization and maturation, growth spurt and body composition. We therefore will investigate those parameters during (pre)puberty, in males presenting conditions with suppressed aromatization (ideopatic osteoprosis) as well as in males with increased aromatization (obesity).
In-capillary drug metabolism study using microsomes and capillary electrophoresis KU Leuven
(Epi)genetic and environmental determinants of muscle and bone mass in relation to steroid hormones in men Ghent University
This study aims to investigate the (epi)genetic determination of peak bone in men. Two large cohorts: (1) a three-generation family-based case-control study including men with idiopathic osteoporosis and their relatives (n=1123), (2) young healthy men (n=768) in a sib-pair design (295 independent families) at age of peak bone mass will be studied. Genetic polymorphisms in the androgen related genes will be studied in relation to volumetric ...
Omics analysis in liquid biopsy samples of advanced tumours Ghent University
Endocrine disrupting activity of in utero exposure to air pollution and its influence on overweight and neurobehavioural development in childhood. Hasselt University
Sex hormone signaling in hepatic metabolic memory Ghent University
Sex hormones are considered as the main drivers for hepatic sexual dimorphism, with male and female livers displaying important differences in physiological and pathological processes. This is exemplified by the higher prevalence of nonalcoholic steatohepatitis (NASH) in men. While being a core element of disease management, weight loss and the associated benefits on hepatic inflammation and fibrosis are difficult to sustain on the long run, ...
PEACE V: a randomized phase III trial for the Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases (STORM) Ghent University
Prostate cancer patients being confronted with a limited nodal recurrence are generally treated with palliative lifelong systemic androgen deprivation therapy with an important negative impact on the quality of life. The current study wants to establish a new standard of care for these patients exploring the potential of local treatments, improving progression-free survival and quality of life.
Clinical and preclinical studies of modulators of high-risk prostate cancer with metastatic potential KU Leuven
The overarching aim of this dissertation is to contribute to both clinical and preclinical knowledge of high-risk localized prostate cancer (PCa).
It is currently accepted that high-risk PCa patients need radical treatment in an attempt to cure their disease. However, there are still important questions related to both oncological and functional outcomes that need to be addressed:
- Currently, the EAU PCa guidelines ...