Projects
Synthesis of simplified ring analogs of (+) - Peloruside A as potential anti-cancer drugs Ghent University
Formulation of hydrophobic anticancer drugs into intelligent polymer nanoparticles Ghent University
solubility and the delivery of taxane anti-cancer drugs. PART I of the thesis comprises a general introduction to scope the need for advanced chemotherapy. Chapter 1 reports on the current treatment modalities for cancer applied in clinic. In particular, anti-cancer drug treatment is described along with the issues of conventional chemotherapy, ...
Implementation of a care pathway for raising adequate, self-management of patients with cancer receiving oral anticancer drugs prescribed Ghent University
Based on the results of two research projects like Leuven and Ghent University commit, in cooperation with '' Come on cancer '' to carry out a project that aims a care pathway for patients with cancer receiving oral anticancer drugs prescribed to implement in five hospitals and a roadmap (including e-learning package) for the implementation of such a pathway, which widely used in hospitals throughout Flanders, compiling. The pathway aims to ...
Effect of pH on colloidal structures in human intestinal fluids and intestinal absorption of anticancer drugs KU Leuven
Oral administration followed by intestinal absorption is the preferred way to deliver drugs to the body. Therefore, estimating the
correct oral dose to achieve a therapeutic effect is an important challenge when developing drug products. Predicting intestinal drug
absorption needs to consider multiple influencing factors, including properties of the drug, the formulation, and the human intestinal
fluids (HIF). One of the ...
Care pathway for adequate self management in patients treated with oral anticancer drugs Ghent University
This study builds on the CONTACT-study, a before-after pilot-study that aims to study the impact of the development, implementation and evaluation of a care pathway for patients treated with oral anticancer drugs (OACD)
The aim of CONTACT-2 is to scale up this pilot study to an additional number of oncology centres in Flanders (N=10). In contrast to CONTACT-1, the development, implementation and evaluation of the care pathway will be ...
Optimization of the anticancer drug target deconvolution process KU Leuven
Novel anticancer drugs can be discovered through large phenotypic screens, without information of their cellular target. However, knowledge of the drug target is desirable for compound optimization and safety assessment. In this PhD project, an in vitro drug target deconvolution pipeline will be tested and optimized, with the goal of accelerating target deconvolution of newly discovered anticancer drugs. In each step, drugs will be tested for ...
Polymeric Engineering of Anticancer Prodrug Nanocrystals and Intracellular Drug Dynamics Investigation KU Leuven
Despite the high toxicitity and the lack of specificity of the drug administered, chemotherapy remains one of the most clinically used cancer treatments. Cancer research have dedicated a lot of attention to the development of efficient and targeted drug delivery systems (DDSs). However, the success is limited by the cytotoxicity of the complex system used and the poor knowledge on the intracellular dynamics of the drug. With this project, we ...
Nanoparticles Engineering towards Targeted Anticancer Drug Delivery and Bio-Sensing KU Leuven
Despite all research efforts over the past decades, cancer remains one of the main causes of death worldwide. With the results reported in this thesis, I give my contribution to fundamental research on cancer by both proposing a novel drug delivery system (DDS), which presented several advantages compared to the existing nanocarriers and by introducing innovative spectroscopic methods for cancer-related investigations.
Polymeric surface ...