Role of axonal transport in amyotrophic lateral sclerosis (ALS) using motor neurons differentiated from induced pluripotent stem cells (iPSCs) KU Leuven
In neurons, axonal transport is a crucial process because of the extreme polarity and size of these cells. Axonal transport supplies the distal part of the axon with newly synthesized proteins and lipids and clears damaged or misfolded proteins. We will investigate the exact role of axonal transport in motor neurons using in vitro models of amyotrophic lateral sclerosis (ALS) caused by mutations in the FUS and TDP-43 gene as well as by ...