Investigating the pathological mechanisms underlying KIF5A mutations in ALS KU Leuven
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease caused by the selective degeneration of motor neurons. It is the loss of contact between motor neurons and muscles that causes the paralysis and death of the ALS patient, on average 2 to 5 years after the diagnosis. In 10% of patients, ALS is a familial disease with causative mutations identified in more than 20 genes. Recently, we identified mutations in kinesin ...