Modeling Amyotrophic Lateral Sclerosis: Human iPSC-derived Astrocytes and Neuromuscular Junctions in Microfluidic Devices KU Leuven
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons in the brain and spinal cord resulting in profound neuronal death and muscle wasting. In 10% of cases, ALS is caused by various inherited mutations, while 90% of cases have a sporadic aetiology. At a cellular level, ALS presents a multifaceted picture with cytoplasmic protein aggregations, axonal transport deficiencies, ...