Biomolecular pathways of orthodontic tooth movement. KU Leuven
We aim to conduct a series of tissue analysis of samples subjected to both conventional and accelerated orthodontic tooth movement (OTM) in animal model.
We aim to conduct a series of tissue analysis of samples subjected to both conventional and accelerated orthodontic tooth movement (OTM) in animal model.
Fluorescence microscopy techniques are indispensable research tools that have enabled live cell imaging with low invasiveness, high sensitivity, and high spatiotemporal resolution. As a result, fluorescence microscopy has revolutionized our understanding of the inner workings of single cells and whole organisms. An integral part of the imaging performance is the fluorescent labels, as the quality of the labels influences the quality of the ...
Fluorescence microscopy is a powerful method to study living systems with high spatial and temporal resolution. However, the resolution of a conventional microscope is limited by diffraction, which precludes the direct visualization of many biological processes occurring at their small scale. During the last decade, several super-resolution fluorescence microscopy methods have been developed that break this diffraction limit and offer a new ...
Furan-modified oligonucleotides and oligopeptides are used in DNA-DNA and DNA-peptide covalent crosslinking. Formation of a site specific, permanent crosslink is of biological importance in the study of DNA repair and cancer treatment. Molecular dynamics and ab-inito quantum chemical (QMMM) calculations, together with NMR prediction will be used to explain and support the experimental work and guide the design of new modifications.
The amalgamation of technology with biology has resulted in a significant improvement both in the quality and the extent of human lifespan. This is more than evident in the current COVID‑19 situation when hospitals and pharmaceutical industry are able to rapidly test millions of people, provide intensive care to those in critical condition and accelerate research to screen for vaccines, thanks to the support provided by technology. However, ...
General purpose. The overall goal of this project is to develop an optimized prototype of the total lab-on-a-chip for cryo- EM solution: cryo-EM affinity grid plus microfluidic chip. Specifically, a microfluidic chip is being developed which it purification of bioparticles (i.e. proteins) and then loading a cryo-EM affinity grid.
Concrete goals and criteria.
-Optimizing and integrating different microfluidic biomolecule ...
The quality of plant-derived foods is rooted on composition and cellular structure of the food matrix. Quality attributes of critical importance in food include colour, flavour and texture. In plant-based foods, cellular structure is mostly dependent on polysaccharides that make up the cell wall and middle lamella. Modifications of these polysaccharides during pre-process storage, processing and/or post-process storage due to enzymatic and/or ...
In cancer, cell division and metastasis require the coordinated activity of a wide range of metal-containing biomolecules, such as proteins, implicated in structural support, enzymatic reactions and electron transfer. Over the last years, modern analytical techniques allowed a better understanding of the cancer biochemistry by acquiring information on the genome, transcriptome, proteome and metabolome. In this project, the metallome –i.e. the ...
Understanding the interplay between animals and microorganisms associated with them has been recognised as an essential step for improving animal health, welfare and production. To understand the biomolecular interactions that impact production processes, researchers are implementing novel analytical strategies based on studying host genomes, their microbial metagenomes as well as the different ‘omic layers interconnecting them. However, such ...