Publications
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The obese brain : the relationship between motor competence, executive functioning and brain structure in children with obesity Ghent University
Persistent Impact of In utero Irradiation on Mouse Brain Structure and Function Characterized by MR Imaging and Behavioral Analysis Vrije Universiteit Brussel KU Leuven
Prenatal irradiation is known to perturb brain development. Epidemiological studies revealed that radiation exposure during weeks 8-15 of pregnancy was associated with an increased occurrence of mental disability and microcephaly. Such neurological deficits were reproduced in animal models, in which rodent behavioral testing is an often used tool to evaluate radiation-induced defective brain functionality. However, up to now, animal studies ...
The effect of long-duration spaceflight on brain structure and function University of Antwerp
In over half a century of crewed missions to space, many different effects of spaceflight on the human body have been uncovered so far. However, little focus has been directed to investigating how space stressors affect the human brain. The largest body of work in this dissertation describes pioneering findings on brain structural and functional changes after spaceflight in Roscosmos cosmonauts by means of multi-modal magnetic resonance imaging ...
Evolution of ASPM coding variation in apes and associations with brain structure in chimpanzees Royal Zoological Society of Antwerp University of Antwerp
Studying genetic mechanisms underlying primate brain morphology can provide insight into the evolution of human brain structure and cognition. In humans, loss-of-function mutations in the gene coding for ASPM (Abnormal Spindle Microtubule Assembly) have been associated with primary microcephaly, which is defined by a significantly reduced brain volume, intellectual disability and delayed development. However, less is known about the effects of ...
Investigating the spectral features of the brain meso-scale structure at rest KU Leuven
Recent studies provide novel insights into the meso-scale organization of the brain, highlighting the co-occurrence of different structures: classic assortative (modular), disassortative, and core-periphery. However, the spectral properties of the brain meso-scale remain mostly unexplored. To fill this knowledge gap, we investigated how the meso-scale structure is organized across the frequency domain. We analyzed the resting state activity of ...
Efficacy of a modern neuroscience approach versus usual care evidence-based physiotherapy on pain, disability and brain structure and function in chronic spinal pain patients: protocol of a randomized clinical trial Vrije Universiteit Brussel Ghent University University of Antwerp
Background
Among the multiple conservative modalities, physiotherapy is a commonly utilized treatment modality in managing chronic non-specific spinal pain. Despite the scientific progresses with regard to pain and motor control neuroscience, treatment of chronic spinal pain (CSP) often tends to stick to a peripheral biomechanical model, without targeting brain mechanisms. With a view to enhance clinical efficacy of existing ...
Among the multiple conservative modalities, physiotherapy is a commonly utilized treatment modality in managing chronic non-specific spinal pain. Despite the scientific progresses with regard to pain and motor control neuroscience, treatment of chronic spinal pain (CSP) often tends to stick to a peripheral biomechanical model, without targeting brain mechanisms. With a view to enhance clinical efficacy of existing ...
Mapping pathological changes in brain structure by combining T1- and T2-weighted MR imaging data KU Leuven
A workflow based on the ratio between standardized T1-weighted (T1-w) and T2-weighted (T2-w) MR images has been proposed as a new tool to study brain structure. This approach was previously used to map structural properties in the healthy brain. Here, we evaluate whether the T1-w/T2-w approach can support the assessment of structural impairments in the diseased brain. We use schizophrenia data to demonstrate the potential clinical utility of the ...
Neurological soft signs in adolescents are associated with brain structure KU Leuven
Neurological soft signs (NSS) are minor deviations in motor performance. During childhood and adolescence, NSS are examined for functional motor phenotyping to describe development, to screen for comorbidities, and to identify developmental vulnerabilities. Here, we investigate underlying brain structure alterations in association with NSS in physically trained adolescents. Male adolescent athletes (n = 136, 13-16 years) underwent a standardized ...
Variation in structure and process of care in traumatic brain injury University of Antwerp
Introduction The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for optimal care for TBI patients. The first step in CER is to map the existing variation. The aim of current study is to quantify variation in general structural and process characteristics among centers participating in the ...