Chemical tools for investigating epigenetic modulation and calcium mediated synaptic plasticity KU Leuven
Epigenetic modulation by HDAC (Histone Deacetylase) inhibition has been linked to improved memory formation due to enhanced synaptic plasticity through calcium mediated pathways. As such, HDACs could be potential drug targets for treating neurodegenerative diseases and depression. However, the physiological changes underlying regiospecific neuronal remodeling by systemic HDAC inhibition are still poorly understood. Therefore, we will ...