Projects
Development and evaluation of specific strategies for the targeted labeling of intracellular structures with quantum dots in live cells Ghent University
The current project focuses on the intracellulair delivery of fluorescent nanomaterials (quantum dots), where several technologies will be evaluated to obtain cytoplasmic delivery. Both heat-generating particles and the combination of ultrasound and quantum dots will be tested in generating membrane pores, where cytoplasmic delivery will be compared to the level obtained by microinjection
Nanodiamond labelling of neuronal cells for molecular resolution neuronal and network-level imaging University of Antwerp
Kit-based labeling of anti-CEA nanobodies for in vivo imaging and therapy of colorectal cancer KU Leuven
In Belgium, colorectal cancer is the third most diagnosed cancer in men and second most diagnosed cancer in women. For efficient treatment and follow-up of patients, it is important to know if the cancer has spread to distant sites (metastases). Positron emission tomography (PET) uses a scanner to track radioactive molecules in the body. Fluorine-18 (18F, a radioactive form of fluorine) is the radionuclide of choice for PET. However, the most ...
Bead-enabled capturing and fluorescent labeling to quantify direct respiratory virus-microbiota interactions. University of Antwerp
Terbium labeling of anti-CEA nanobodies for in vivo imaging and therapy of colorectal cancer KU Leuven
In Belgium, colorectal cancer is the third most diagnosed cancer in men and second most diagnosed cancer in women. Nuclear medicine plays an important role in the diagnosis, follow-up and treatment of cancer. Ideally, the diagnostic radiopharmaceutical has an identical chemical structure than the therapeutic radiopharmaceutical, so that the pharmacokinetic properties of both compounds are equal, and that accurate dosimetry is possible. This ...
Programmable proximal protein labeling of long non-coding RNAs in cancer Ghent University
The human genome is estimated to contain approximately 20.000 to 25.000 genes, which accounts
for about 2% of the genomic DNA. Since the 1960s, the remaining 98% or non-coding DNA has
been referred to as “junk” DNA and was thought to have no molecular function in the cell.
Recently, however, it has been shown that this “junk” DNA has a prominent role in normal cellular
functioning. The bulk of “junk” DNA is being ...
The BD FACS Symphony FACS cell sorter: the most advanced multiparameter fluorescence activated cell sorter that allows the identification and purification of rare cells for further functional characterization Ghent University
To be in a position to better understand the roles played by different immune cells in healthy and disease settings we must first be able to purify these cells. Only once we can obtain these cells as a pure fraction can we truly assess their individual contributions in any given setting. In recent years, our ability to discriminate between different cells types that often look similar has improved dramatically. By marking the cells with many ...