Projects
Evaluation of an anti-idiotype NanoCAR-T cell approach for the treatment of Multiple Myeloma Vrije Universiteit Brussel
Large scale microfluidics-based optimization of synthetic biology circuits and cell reprogramming KU Leuven
The study of biology evolves increasingly to the detailed analysis of a single cell. Massive engineering and analysis of single cells represents the final frontier of biology. Solid technology is now available to study the genomic code of a single cell, as well as the messenger molecules (mRNA) it produces. The analysis of proteins, the actual functional molecules in the cell, lags far behind because of technical hurdles. In this project we ...
Linking properties of biomimetic polymer matrices to stem cell fate: a microscopy study KU Leuven
Living tissues are more than packed cells. In fact, much of a tissue's volume is made up of extracellular space, filled with a complex meshwork of sugars, water, minerals and proteins called the extracellular matrix (ECM). Besides providing a structure support to the cells, the ECM plays a crucial role in several cellular processes, such as cell survival, development, adhesion and differentiation of stem cells. When a stem cell divide, it ...
Large scale microfluidics-based optimization of synthetic biology_x000D_ circuits and cell reprogramming Ghent University
The study of biology evolves increasingly to the detailed analysis of a single cell. Massive engineering and analysis of single cells represents the final frontier of biology. Solid technology is now available to study the genomic code of a single cell, as well as the messenger molecules (mRNA) it produces. The analysis of proteins, the actual functional molecules in the cell, lags far behind because of technical hurdles. In this project we ...
Development of novel cell death PET imaging probes for early treatment response evaluation University of Antwerp
Investigating the post-translational control of SOMBRERO, a key transcription factor of plant programmed cell death Ghent University
The Arabidopsis NAC transcription factor SOMBRERO (SMB/ANAC033) is a key regulator of root cap differentiation. Expressed directly after the formative division of root cap stem cells, it regulates exit from the stem cell fate and promotes root cap maturation. SMB also controls the timely execution of programmed cell death (PCD) and post-mortem corpse clearance of root cap cells. I hypothesise that the precise timing of SMB activities is ...
Investigation of non-thermal plasma therapy with first-line treatments of recurrent and metastatic head and neck squamous cell carcinoma: a novel combination with platinum-based chemotherapy and immunotherapy. University of Antwerp
Leveraging patient-driven research to improve rational therapy selection in (ROS1+) non-small cell lung cancer. University of Antwerp
In situ, spatially resolved 'omits' at the single cell level, unlocked through expansion microscopy KU Leuven
Cells are the fundamental functional units in all forms of life. Even though largely
all cells in a human body carry the same genetic information, we still know
surprisingly little about their detailed composition. This is due to the vast
amount of variation in a cell’s gene expression. Specifically, each cell at a certain
moment in time has a certain set of genes that are switched on or off, resulting
in different ...