Projects
Study of the role of adult neurogenesis in the olfactory bulb by optogenetic neuromodulation. KU Leuven
It is established that neurogenesis persists in the adult brain of all mammals including humans. Interestingly, this phenomenon is restricted to two specific brain areas consisting of the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus (HC). The existence of adult neurogenesis throughout adult life created the hope for brain repair by cell replacement of the cells lost during neurodegenerative ...
Alpha-particle therapy with CS1-specific nanobodies to tackle residual cancer cells in Multiple Myeloma. Vrije Universiteit Brussel
FWO-SB-Beurs: Innovating Yeast Display for the selection of nanobodies for difficult targets Vrije Universiteit Brussel
Development of a new, miniaturized 18F marking method for proteins and peptides with 18 F-FDG as a building block Ghent University
In the current proposal, we like would like to explore : (1) the possibility of using 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) as a building block for the radiosynthesis of 18F-labeled compounds. Being the most important radiotracer for PET imaging in nuclear medicine, [18F]FDG is available in almost every PET center. The [18F]FDG based building blocks will then be evaluated for the labeling of proteins, using in ...
Prenatal diagnosis via cervical cells KU Leuven
Prenatal genetic testing enables the detection of genetic disorders and allows parents to make an informed decision about the pregnancy. The golden standard is invasive prenatal testing of fetal or placental DNA based on amniocentesis or chorionic villous samples, respectively. Due to the associated risks, non-invasive prenatal testing is preferred. Over the last decade, non-invasive prenatal screening (NIPS) of cell-free fetal DNA obtained ...
Vitamin D analogs in combination with palbociclib as treatment for triple-negative breast cancer – preclinical evaluation and pathway analysis KU Leuven
1,25(OH)2D3, the biological active form of vitamin D3, is an important regulator of calcium and phosphate homeostasis in the body. By binding to the vitamin D receptor (VDR) and subsequent heterodimerization with the retinoid X receptor (RXR), this complex will migrate to the nucleus and bind to vitamin D responsive elements (VDREs) in regulatory regions of target genes to regulate gene transcription. Next to calcium and phosphate ...
The role of peri-synaptic astrocytes in synaptic plasticity KU Leuven
Sleep, an omnipresent behaviour spanning the animal kingdom, is mostly investigated from a behavioural and cell network perspective. Since rest-states are observed also in animals with different organizations of the nervous system, questions arise as to whether we can find molecular correlates of sleep at a smaller unit: an individual cell, and if such correlates are different depending on the cell’s identity.
Through a comprehensive ...