Projects
Studying Dscam function in synaptic connectivity at single cell level. KU Leuven
Axonal branching is an essential mechanism in nervous system function, as it allows a single neuron to connect to multiple post-synaptic targets and thus increases the complexity and connectivity of neural networks. Collateral formation could be a therapeutic target to promote functional recovery in a wide range of nervous system diseases and injuries. However, the mechanisms allowing the formation and stabilization of specific ...
The diagnostic and therapeutic potential of the tumor associated antigene xvB5 in non-small cell lung cancer Ghent University
The purpose of the proposal encloses the development of recombinant, humanised anti-xvB5 antibody fragments adapated for radio-immunotherapy and radio-diagnosis in the treatment of non-small cell lung cancer. The biotechnological engineering, the labelling with radio-isotopes and the in vitro and in vivo evaluation in an experimental animal model will be investigated in the research project.
The search for cancer-related biomarkers: a technological challenge KU Leuven
Corpus linguistics in the Greek papyri: developing a corpus to study variation and change in the post-classical Greek complementation system KU Leuven
The aim of this PhD project is to advance the corpus-linguistic study of the Greek papyri, a large diachronic corpus (3rd century BC – 8th century AD) of non-literary Greek. It consists of two central parts. The first part is focused on corpus design: starting from the transcribed (XML) version of these texts, it describes a pipeline model to supply the papyri step for step with linguistic information, using natural language ...
Fluorine-19 Magnetic Resonance Imaging as a Potential Tool in Preclinical Research --- With Focus on Diabetes KU Leuven
Diabetes remains one of the increasing threats to human health with over 422 million people suffering from the disease all over the world. Despite the advancements in understanding the disease and improvements in treatment, diagnosis and early prevention with effective monitoring of pre- and post- therapy of the disease is still urgently needed. Hereby, the function and mass of pancreatic islets (PIs) and in particular their beta cells play ...
Development of integrated single virus technology to study the early replication steps of HIV KU Leuven
HIV-1 requires various interactions with cellular cofactors to complete its viral replication cycle. In the first place, viral entry involves the interaction of the viral envelope protein with the host cell CD4-receptor and the CXCR4 or CCR5 co-receptor, resulting in membrane fusion and the release of the viral cone into the cytoplasm of the host cell. During the transport to the nucleus, the viral RNA is converted into double-stranded viral ...
Assessing dimerization-based regulation of GPCRs using live-cell activity and interaction sensing in genomically-labelled neurons KU Leuven
G-protein coupled receptors (GPCRs) are the eyes and ears of the cell. They are heavily implicated in cell functioning and disease. All GPCRs appear to signal via a few highly conserved pathways, raising the question of how cells maintain signaling specificity. Homo- and hetero-dimerization of GPCRs is thought to be an important regulatory mechanism, though its role remains poorly understood partly due to conflicting experimental results.
...