Optimisation of a aVB3 targeted Nanobodies for cancer therapy, cancer imaging and targeted delivery. Ghent University
Tumor necrosis factor (TNF)' has excellent anti-tumor capacities. Unfortunately its systemic use is accompanied by severe side effects due to the strong pro-inflammatory nature of TNF. To circumvent this toxicity. the anti-tumor effects of TNF can be mimicked in a non-toxic manner. It is believed that the anti-tumor effects are
mediated in part through the inactivation of the integrin aV133. This integrin is a useful target for ...