Pathophysiological characterization of megakaryopoiesis and platelet production: omics for thrombocytopenia and functional studies. KU Leuven
Platelets, the 2nd most abundant cell in the blood, play a pivotal role in cardiovascular diseases. The number, volume and function of platelets vary widely in the healthy population and are highly heritable. Genome-wide association studies have delivered information on common sequence variation in known but also novel genes that control these 3 traits. On the other end of the spectrum of sequence variation, known and hitherto not yet defined ...