Projects

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The beta-cell and the immune system in type 1 diabetes: partners in crime - developing new therapies in type 1 diabetes through better understanding of beta-cell behaviour and use of novel immunomodulators. KU Leuven

Chantal Mathieu
Clinical and Experimental Endocrinology
Type 1 diabetes (T1D) is a lifelong autoimmune disease where the immune system selectively destroys the pancreatic insulin-producing beta-cells leading to absolute insulin deficiency. Although our understanding of the (immune) mechanisms involved in T1D is growing, it still remains incomplete but the beta-cell has been positively identified as both driver and target of the disease. The steep increase in incidence and the younger age at onset ...

The beta-cell and the immune system in type 1 diabetes: partners in crime - developing new therapies in type 1 diabetes through better understanding of beta-cell behaviour and use of novel immunomodulators. KU Leuven

Chantal Mathieu
Clinical and Experimental Endocrinology, Gene Expression Unit
Prevention of type 1 diabetes (T1D), the most common metabolic disease in childhood and adolescence, remains an elusive goal, with therapy after therapy failing to demonstrate long-term efficacy in arresting the autoimmune attack against the pancreatic insulin-producing beta-cell in people at risk for or with recent T1D. We propose to pursue an integrated approach, recognizing the crucial role of both the immune system and the beta-cell in the ...

Translational approaches to disease modifying therapy of type 1 diabetes: An innovative approach towards understanding and arresting Type 1 diabetes – time to harvest. KU Leuven

Chantal Mathieu
Clinical and Experimental Endocrinology
In the previous 4 years, the INNODIA project has built a landmark sample collection network in Europe and has established the go-to platform for clinical trials in T1D intervention, aimed at achieving protection of functional beta-cell mass.In a close collaboration between basic, translational and clinical researchers, industry partners, foundations and also people living with T1D we have built a platform of biomarker analysis using standardized ...

Boosting beta-cell function for treatment of type 1 diabetes KU Leuven

Chantal Mathieu
Clinical and Experimental Endocrinology

In type 1 diabetic (T1D) patients the pancreatic insulin-producing beta cells are selective destroyed by the immune system, leading to an impaired glucose metabolism. The steep increase in the incidence of this chronic autoimmune pathology especially in young children in the last decades raises serious concerns. To date, insulin therapy is considered the gold standard for the treatment of T1D. Nevertheless, limitations persist, such as the ...

The Belgian Diabetes in Pregnancy follow-up study (BEDIP FUS) KU Leuven

Katrien Fouzia Benhalima
Clinical and Experimental Endocrinology
Gestational diabetes (GDM) is a form of diabetes that develops during pregnancy. Women and children with a history of GDM have a high risk to develop type 2 diabetes (T2DM) after delivery. In this research project we will investigate how the long-term metabolic risk can more accurately be predicted in a follow-up cohort of the ‘Belgian Diabetes in Pregnancy study’ (BEDIP-N). We will study the relationship between maternal weight, degree of body ...

Closed-loop insulin delivery in pregnant women with type 1 diabetes (the CRISTAL study) KU Leuven

Katrien Fouzia Benhalima
Clinical and Experimental Endocrinology

Type 1 diabetes (T1DM) during pregnancy is associated with increased risk of maternal and neonatal complications such as pre-eclampsia, preterm delivery, caesarean sections, congenital malformations and perinatal mortality. Even with increasing use of new continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII, insulin pumps) technologies, pregnant women with T1DM continue to spend on average 8 hours/day ...

Aspalathus Linearis: a new type 2 diabetes antidote in humans? Hasselt University

Cardio & organ systems, Stellenbosch University
Physical activity and a healthy diet are excellent modifiers of obesity and type 2 diabetes in humans. Excercise increases sensitivity of insulin in tissues and enhances glycaemic control. Interestingly, foods that contain flavonoids also have positive effects on diabetes and obesity because of their reported anti-inflammatory and anti-oxidant effects. Aspalathus Linearis, a plant rich in flavonoids could be such a food supplement. Despite the ...

Breath analysis as a non-invasive biomarker for the early detection of preclinical type 1 diabetes. University of Antwerp

Eveline Dirinck
Laboratory Experimental Medicine and Pediatrics (LEMP)
Type 1 diabetes mellitus (T1DM) is an auto-immune disorder, causing destruction of the insulin producing β-cells. Often, people with T1DM have auto-antibodies on a predisposing genetic background (HLA genotype). In Belgium, new diagnoses are reported to the Belgian Diabetes Registry (BDR), as they offer free risk-stratification (auto-antibody detection and HLA class) and follow-up of patients and first-degree relatives. Autoantibodies can be ...

SRP (Groeiers): Regenerative therapy in diabetes Vrije Universiteit Brussel

Luc Bouwens
Medical Biochemistry, Pathological Anatomy
Diabetes results from an insufficient number of insulin-secreting beta cells in the pancreas. In the case of Type 1 diabetes there is a gradual depletion of the beta cell mass whereas in Type 2 diabetes the beta cells fail to increase their number to compensate for increased insulin demands. Transplantation of beta cells from cadaveric organ donors has the potential to cure T1D but this therapy is significantly hampered by the shortage of organ ...

Cost effectiveness of levels of implementation of integrated Chronic care for Diabetes and its Comorbidities across different primary care practices in Flanders (COSDCOM). University of Antwerp

Edwin Wouters
Primary and interdisciplinary care Antwerp (ELIZA), Centre for Population, Family and Health
The increasing prevalence of Type 2 Diabetes (T2D) and the frequent concurrence of comorbidity puts a heavy strain on societies (both the patients and health system), in terms of healthcare cost, patients' quality of life and loss of productivity. Interventions such as Integrated Chronic Care (ICC) and disease specific care trajectories are introduced to better address these complex needs but there is limited evaluation of these interventions. ...