Projects
Cost effectiveness of levels of implementation of integrated Chronic care for Diabetes and its Comorbidities across different primary care practices in Flanders (COSDCOM). University of Antwerp
Elucidating the contribution of NAFLD (non-alcoholic fatty liver disease) and insulin resistance in the development of cardiovascular complications in people with type 1 diabetes. University of Antwerp
Unravelling chronic postsurgical pain after total knee replacement: what is the role of altered central pain processing and metabolic disorders such as obesity and diabetes? University of Antwerp
Innovative strategies for screening, diagnosis and prevention of type 1 diabetes. KU Leuven
Influence of glycemic variability on autonomic and cardiovascular function, and its modulation by postprandial exercise training in patients with diabetes type 1 Ghent University
Type 1 diabetes is characterized by chronic hyperglycemia and by acute glycemic fluctuations. The role of this glycemic variability (GV) in the development of diabetic complications is subject of debate. In this study we want to evaluate the impact of GV on autonomic function and vascular complications, as well as to investigate the effects of postprandial exercise on these parameters.
Development of novel selective ghrelin O-acyltransferase inhibitors for the treatment of obesity and obesity-related type 2 diabetes KU Leuven
Ghrelin is currently the only circulating orexigenic hormone, which acts to modulate the body's energy and glucose homeostasis. The acylation of ghrelin, necessary for its biological activity, is mediated by a unique enzyme, GOAT. Inhibition of GOAT and thus of acylated ghrelin levels should decrease food intake and fat storage and increase insulin secretion. In this way, GOAT inhibitors constitute an attractive target for the treatment of ...