Projects
Development of 3D printed biopolymeric scaffolds for beta cells: towards improving the quality of life of diabetics. Ghent University
Diabetes is a leading cause of death worldwide, with over half a billion adults living with the condition in 2021. Although there is no cure for either type I or type II diabetes, there are various ongoing studies exploring different solutions to improve patients' quality of life. One possible solution is to develop a system that mimics the natural functions of pancreatic beta cells, including insulin secretion. An artificial pancreas, beta ...
Towards a targeted therapy for diabetic neuropathy: a cross-sectional study and exercise training intervention to improve pathophysiological understanding. Ghent University
Approximately 50% of all patients with type 2 diabetes mellitus (T2DM) develop diabetic neuropathy (DNP), which leads to a decrease in muscle mass and strength. This sarcopenic effect can theoretically be attributed to a shift in muscle fiber type and a negative protein turnover, resulting from reduced mitochondrial function and inflammation. There are some studies that report a shift to a more anaerobic type IIx fibers in the case of T2DM, ...
Toward 4D-printed foot orthotics by pressure-driven shape adaptability for the remote management of at-risk diabetic feet KU Leuven
Development, validation and implementation of novel strategies and technologies allowing the evaluation of newly emerging predictors of diabetic complications. Ghent University
Diabetes, together with its long-term complications, is without a shadow of a doubt one of the main challenges for today's healthcare. The proposed project aims at developing new chromatographic strategies that allow the detection of predictive markers for diabetic complications with high sensitivity and selectivity. Therefore, we will make use of dried blood spots.
Robust identification of patient-specific parameters for bolus calculators in type 1 diabetic patients KU Leuven
Identification of small molecule ErbB4 agonist for treatment of heart failure, diabetic kidney injury and fibrotic disorders. University of Antwerp
Circulating histidine-containing dipeptides and the development of diabetic nephropathy: role of exercise and supplementation Ghent University
Both supplementation with the dipeptide carnosine and aerobic training have been shown, at least in rodents, to protect against the development of diabetic nephropathy. The goal of this project is to elucidate whether this exercise-induced protection can be attributed, at least partly, to elevated circulating histidine-containing dipeptides levels.
Mechanisms of the delayed-oxygen uptake kinetics and reduced exercise tolerance in type 2 diabetics. Ghent University
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