Unraveling the nature of chromosomal instability during early embryogenesis KU Leuven
Human conception is hampered by a low birth rate and infertility. Early miscarriages are often characterized by chromosomal aberrations in the embryo. With the advent of a new methodology, haplarithmisis, for pre-implantation genetic diagnosis (PGD) it is possible to perform haplotyping and copy number profiling on a single cell.
By applying this methodology on bovine embryos, we discovered a so far unknown type of cell division. In ...