Projects
Epigenetic approach to ALL combinational therapies. KU Leuven
T-ALL is a complex cancer in which multiple lesions accumulate in the genome of hematopoietic progenitors. One frequent alteration is the activation of JAK/STAT pathway, leading to increased cell proliferation and survival. These alterations also affect epigenetic regulators, altering the epigenetic landscape of leukemic cells and further contributing to cancer development. Although current therapy has increased T-ALL prognosis, it is highly ...
Exploring the father’s role in succesful pregnancy and signatures of epigenetic inheritance from sperm to offspring: an approach through biostatistics and computational modeling methods. KU Leuven
The effects of a mother's environment during pregnancy on her children's health have been studied extensively. However, recent findings suggest that a father’s environment and his age before conception matters as well. This runs counter to standard thinking about heredity that parents pass down only genes to their children. An equally plausible way to leave a mark on offspring is through epigenetic inheritance. This refers to molecular ...
A single-cell approach to study epigenetic regulation of Plasmodium knowlesi phenotypes: red blood cell invasion and gametocyte differentiation processes Institute of Tropical Medicine
A precision medicine approach for canine degenerative myelopathy combining genetic and epigenetic alterations Ghent University
This project aims to introduce precision medicine and epigenetics research in the canine neurogenetics field. Practically, canine degenerative myelopathy will be studied with MBD-seq to identify differentially methylated regions associated with disease progression. This will be followed by the writing of a general statistical analysis framework in R that accurately predicts clinical age ofonset for this disorder.
A multi-omics approach to the detection of pathologic genetic and epigenetic lesions in Developmental and Epileptic Encephalopathies University of Antwerp
A precision medicin approach for canine degenerative myelopathy combining genetic and epigenetic alterations Ghent University
This research project aims to introduce precision medicine and epigenetics research in the canine neurogenetics field. Practically, canine degenerative myelopathy will be studied with MDB-seq to identify differentially methylated regions associated with disease progression. This will be followed by the writing of a general statistical analysis framework in R that accurately predicts clinical age of onset for this disorder.
(Epi)Genetic studies and system biology approaches to characterize rare inherited bleeding and platelet disorders: from patient studies to basic biology to cl inical applications KU Leuven
In this OT project, (epi)genetic large-scale studies in combination with functional in vitro studies will be used to characterize patients with “rare inherited Bleeding and Platelet Disorders (BPDs)”. (Epi)Genetic studies and system biology approaches to characterize rare inherited bleeding and platelet disorders: from patient studies to basic biology to clinical applications.
Paving the way to precision medicine in childhood-onset diseases: A lifespan perspective on accelerated aging using the epigenetic clock KU Leuven
Many childhood-onset diseases used to be lethal. Improved life
expectancy yield that most patients can survive into adulthood, to
date. However, survivors of childhood-onset diseases often develop
morbidities that suggest accelerated aging. Congenital heart disease
is a typical example of a childhood-onset disease. It is the most
common birth defect, comprising a spectrum of mild, moderate and
complex heart ...