Publications
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Lighting up the plasma membrane: Development and applications of fluorescent ligands for transmembrane proteins. Flanders Institute for Biotechnology KU Leuven
Synthesis of highly fluorescent copper clusters using living polymer chains as combined reducing agents and ligands Ghent University
Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes As Revealed by Intrinsic Tryptophan Fluorescence Quenching KU Leuven
TRPV3 is a thermosensitive ion channel primarily expressed in epithelial tissues of the skin, nose and tongue. The channel has been implicated in environmental thermosensation, hyperalgesia in inflamed tissues, skin sensitization and hair growth. While TRP channel research has vastly increased our understanding of the physiological mechanisms of nociception and thermosensation, the molecular mechanics of these ion channels are still largely ...
Rational Design, Synthesis, and Spectroscopic and Photophysical Properties of a Visible-Light-Excitable, Ratiometric, Fluorescent Near-Neutral pH Indicator Based on BODIPY Hasselt University KU Leuven
A visible-light-excitable, ratiometric, brightly fluorescent pH indicator for measurements in the pH range 5-7 has been designed and synthesized by conjugatively linking the BODIPY fluorophore at the 3-position to the pH-sensitive ligand imidazole through an ethenyl bridge. The probe is available as cell membrane permeable methyl ester 8-(4-carbomethoxyphenyl)-4,4-difluoro-3-[2-(1H-imidazol-4-yl)ethenyl]-1, ...
Ligand interaction and dynamics in CdSe Quantum dot dispersions: a solution NMR investigation Ghent University
Quantum dots are inorganic nanocrystals of great interest in todayU+2019s research due to their optical properties. Their tunable bandgap opens a wide range of possible applications in areas such as light emitting diodes, fluorescent markers, lasers, solar cells and NIR communication devices. Most of their handling, synthesis and modification is done in colloidal dispersion using organic capping ligands. To stabilize the nanocrystal dispersion, ...
AgTx2-GFP, Fluorescent Blocker Targeting Pharmacologically Important Kv1.x (x=1, 3, 6) Channels KU Leuven
The growing interest in potassium channels as pharmacological targets has stimulated the development of their fluorescent ligands (including genetically encoded peptide toxins fused with fluorescent proteins) for analytical and imaging applications. We report on the properties of agitoxin 2 C-terminally fused with enhanced GFP (AgTx2-GFP) as one of the most active genetically encoded fluorescent ligands of potassium voltage-gated Kv1.x (x = 1, ...
Fabrication of 3D Oriented MOF Micropatterns with Anisotropic Fluorescent Properties KU Leuven
Micropatterning crystalline materials with oriented pores is necessary for the fabrication of devices with anisotropic properties. Crystalline and porous metal-organic frameworks (MOFs) are ideal materials as their chemical and structural mutability enables precise tuning of functional properties for applications ranging from microelectronics to photonics. Herein, a patternable oriented MOF film is designed: by using a photomask under X-ray ...