Identification of the mast cell-related immune mechanisms underlying the development of visceral pain in irritable bowel syndrome KU Leuven
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal discomfort and pain, associated with altered defecation, in the absence of an organic cause. The most consistent symptom of IBS is abdominal pain, resulting from visceral hypersensitivity (VHS), one of the hallmark features of IBS. In IBS patients, VHS has been shown to result from an abnormal activation of mast cells. Targeting the mechanisms ...