Wei-Na Cong, Wayne Chadwick, Rui Wang, Caitlin M. Daimon, Huan Cai, Jennifer Amma, William H., III Wood, Kevin G. Becker, Bronwen Martin,
Stuart Maudsley, et al.
Huntington′s disease (HD) is a neurodegenerative disorder characterized by progressive motor impairment and cognitive alterations. Hereditary HD is primarily caused by the expansion of a CAG trinucleotide repeat in the Huntingtin (Htt) gene, which results in the production of mutant huntingtin protein (mHtt) with an expanded amino-terminal polyglutamine (PolyQ) stretch. Besides pathological mHtt aggregation, reduced brain-derived neurotrophic ...