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Genetic Counselling in Belgium: the Centre for Human Genetics at the University of Leuven, 1960-1990 KU Leuven
© Springer International Publishing AG 2017. All rights reserved. This chapter traces the history of the Center for Human Genetics (CHG)- the first centre of this kind in Belgium-at the University of Leuven from the 1960s to the 1990s. In 1960, a laboratory for diagnostic chromosomal research was set up by the physician and geneticist Herman Van den Berghe. In 1966, this laboratory was turned into the Center for Human Genetics (CHG), which ...
Gene Prioritization Through Genomic Data Fusion: Methods and Applications in Human Genetics (Gen prioritizatie via genomische data fusie: Methodes en toepassingen in menselijke genetica) KU Leuven
Unravelling the molecular basis underlying genetic disorders is crucial in order to develop effective treatments to tackle these diseases. For many years, scientists have explored which genetic factors were associated with several human traits and diseases. After the completion of the human genome project, several high-throughput technologies have been designed and widely used, therefore producing large amounts of genomic data. At the same time, ...
Statement of the ESHG on direct-to-consumer genetic testing for health-related purposes European Society of Human Genetics KU Leuven
Many private companies offer direct-to-consumer (DTC) genetic testing services. Some tests may detect severe and highly penetrant monogenic disorders, while other tests are for genetic variants found associated with increased susceptibility for common and complex diseases in large-scale population studies. Through its Public and Professional Policy committee followed by member and expert consultation, the European Society of Human Genetics has ...
Human Genetics Society of Australasia Position Statement: Predictive and Presymptomatic Genetic Testing in Adults and Children KU Leuven
In 2020, the Human Genetics Society of Australasia released its Position Statement on Predictive and Presymptomatic Genetic Testing in Adults and Children. This Position Statement synthesizes the major practical, psychosocial and ethical considerations associated with presymptomatic and predictive genetic testing in adults who have the capacity to make a decision, children and young people who lack capacity and adults living with reduced or ...
Human Genetics Society of Australasia Position Statement: Genetic Carrier Testing for Recessive Conditions KU Leuven
This Position Statement provides guidelines to assist all health professionals who receive requests for carrier testing and laboratory staff conducting the tests.In this Statement, the term 'carrier testing' refers to genetic testing in an individual to determine whether they have inherited a pathogenic variant associated with an autosomal or X-linked recessive condition previously identified in a blood relative. Carrier testing recommendations: ...
Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policyEuropean Society of Human Genetics and European Society of Human Reproduction and Embryology KU Leuven
In March 2005, a group of experts from the European Society of Human Genetics and European Society of Human Reproduction and Embryology met to discuss the interface between genetics and assisted reproductive technology (ART), and published an extended background paper, recommendations and two Editorials. Seven years later, in March 2012, a follow-up interdisciplinary workshop was held, involving representatives of both professional societies, ...
Unifying Viral Genetics and Human Transportation Data to Predict the Global Transmission Dynamics of Human Influenza H3N2 KU Leuven
Information on global human movement patterns is central to spatial epidemiological models used to predict the behavior of influenza and other infectious diseases. Yet it remains difficult to test which modes of dispersal drive pathogen spread at various geographic scales using standard epidemiological data alone. Evolutionary analyses of pathogen genome sequences increasingly provide insights into the spatial dynamics of influenza viruses, but ...
Textbook of Human Reproductive Genetics Vrije Universiteit Brussel
Genetic advances in the reproductive sciences are arguably occurring with greater rapidity than that of any other organ system. Not only have the dazzling technological advances of molecular genetics become applicable in reproduction, but meteoric advances are occurring in diagnosis and treatment. Assisted reproductive technology (ART) has rendered infertility far less daunting. Yet treating such couples, that once would not have conceived, may ...