Blockade of the VSIG4 immune checkpoint molecule as novel cancer therapy Vrije Universiteit Brussel
Though the effect of ...
Long-term treatment of autoimmune disorders is still an unmet clinical need. In this project, we will develop an innovative therapy to realize long-term treatment of autoimmune disorders. The autoimmune disorder immune-mediated thrombotic thrombocytopenic purpura (iTTP) will serve as the disease model as the autoimmune response in iTTP is well known and autoantibodies are directed against only one antigen. As an innovative therapy, we will ...
CAR T-cell therapy has recently emerged as a novel important therapeutic
tool in patients with advanced B cell malignancies. This treatment is targeting
specifically the CD19 expression on B lymphocytes and has shown
remarkable efficacy even in patients with relapsed / refractory disease. While
showing promising results, there is to date, very little known on the immune
mechanism supporting long-term response. Using ...
Despite evidence associating colorectal cancer (CRC) and microbiome, its role in metastatic CRC remains
unexplored. In this project, we aim to characterize bacterial colonization of CRC metastases matched with
primary tumors, surrounding normal tissues and evaluate its relationship with tumor characteristics, including
molecular subtype, pattern of histological growth, local immune response and alteration in T-cell antigen ...