Projects
IL-13-overexpressing anti-inflammatory macrophages suppress trauma induced premature immune aging. Hasselt University
Immunogenic cancer cell death: From molecular determinants and immune responses to pre-clinical immunotherapy. KU Leuven
The beta-cell and the immune system in type 1 diabetes: partners in crime - developing new therapies in type 1 diabetes through better understanding of beta-cell behaviour and use of novel immunomodulators. KU Leuven
A Tumor Immune Micro Environment (TIME)-on-chip: an in vitro model for immuno-oncology and immunotherapy screening KU Leuven
Cystic fibrosis (CF) is an inherited life-threatening monogenic disorder that affects approximately 80,000 people worldwide. It is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene that encodes for the chlorine/bicarbonate ion channels. It causes severe damage to the lungs, digestive system, and several other organs in the body as a result of mucus buildup, impaired bacterial killing, and inflammation. ...
Immune profiling of CIDP (IPoC). KU Leuven
Insulin and the immune response to critical illness KU Leuven
In order to survive, the human body has to protect itself against the continuous threat of external aggressions, as well as against endogenous stress caused by ageing, dysfunctional, mutated or damaged cells. In conditions of extreme stress, the organism will either recover quickly and survive, or will succumb. Thanks to innovations in intensive care medicine, patients are nowadays able to survive such acute life-threatening conditions. ...
Local and systemic immune interactions in malignant gliomas KU Leuven
Glioblastoma (GBM), the most frequent primary intrinsic brain tumor, is without any doubt one of the most devastating diseases known to mankind. GBM are currently being treated with neurosurgical resection followed by radio- and chemotherapy. However, despite this treatment, prognosis for these patients is grim with a median survival of only 15 months and less than 20% 3-year survival rates. Already at diagnosis, GBM cells are infiltrating ...