Projects
Hybrid CAR – improving cellular therapies for infectious diseases Ghent University
In this project we aim to develop a Chimeric Antigen Receptor (CAR) T cell-based therapy against a viral infection, where virus becomes effectively eliminated from the patient’s organism. CAR T cell therapy has been successfully applied to treatment of haematological malignancies, but its usage to treat viral infections so far has failed clinical trials. The novelty of our approach consists in targeting not only infected host’s cells ...
GEAR: Integrating a multimodal approach to address current challenges in immunotherapy (INTEGRAL) Vrije Universiteit Brussel
IOF Accelerator:Integrating a multimodal approach to address current challenges in immunotherapy (INTEGRAL) Vrije Universiteit Brussel
traditional therapies such as surgery, radiotherapy and chemotherapy. However, not all patients respond equally well to
immune-based therapies, highlighting the need for improving immunotherapy outcome. The INTEGRAL IOF programme aims
to reinforce the complementary offering of expertise, know-how, ...
Targeting lipid metabolism to overcome cancer therapy resistance KU Leuven
Enhancing tumor cell susceptibility towards natural killer cell and dendritic cell-mediated activity in the context of cancer immunotherapy University of Antwerp
Infectious Center One Health (ICOH) Ghent University
ICOH is a university-Âwide research center that gathers buildings, infrastructure, inspection bodies and expertise that forms an environment to perform experimental infections in animals in a biosafe and ethically/legally correct way. In the animal facilities, researchers may work with pathogens from risk category 2/3 to work under optimal conditions (controlled ventilation/lighting/temperature/relative humidity, decontamination of ...
Immunogenic cancer cell death: From molecular determinants and immune responses to pre-clinical immunotherapy. KU Leuven
Towards an Off-the-Shelf Therapy: Tolerogenic Dendritic Cell-derived Extracellular Vesicles for the Treatment of Multiple Sclerosis. University of Antwerp
Backup mandate from Research Council: TITAN: imaging and manipulation of Tumor-Infiltrating T-cells using Anti-CD3 Nanobodies Vrije Universiteit Brussel
Harnessing the immune system, in particular T-cells, holds the
promise of eradicating breast cancer cells with exquisite precision. Moreover, the immunological memory formed by T-cells ensures long-lasting response. Several T-cell centered immunotherapies are under construction for the treatment of breast cancer, a.o. immune checkpoint blockade and immunization strategies. ...