Tackling arachidonic acid metabolism in macrophages to overcome immunesuppression and immunotherapy resistance KU Leuven
Tumor metabolism has gained a lot of interest in the last years and, in the immunology field, it became clear that metabolic modulations can play an important role in shaping the immune response towards cancer cells. To identify metabolic features that can be associated with immunotherapy resistance we performed a meta-analysis of transcriptomic and metabolomic data sets. The bicarbonate-importer Slc4a4 and an enzyme involved in arachidonic ...