Projects
Understanding and building trust in in silico medicine: A sociological analysis of medical experts’ and clinicians’ perspectives on in silico medicine KU Leuven
In general, the main objective of my doctorate would be to investigate in depth the concept of trust in the emerging field of in silico medicine, with a specific focus on the perspectives of medical experts and clinicians, as well as trust on the patient’s side, now in silico medicine is still in the making. I will aim to identify the different elements that influence trust in innovative medicine.
In Silico World: Lowering barriers to ubiquitous adoption of In Silico Trials KU Leuven
The overall aim of the In Silico World project is to accelerate the uptake of modelling and simulation technologies for the development and regulatory assessment of all kind of medical products. This will be achieved by supporting the trajectory of a number of In Silico Trials solutions through development, validation, regulatory approval, optimisation, and commercial exploitation. These solutions, already developed to different stages, ...
In silico simulation of the degradation of wood and wood products byIn silico simulation of the degradation of wood and wood products by Fungi. Ghent University
As wood is prone to biological degradation, it is necessary to gather knowledge concerning its susceptibility to fungal attack to strengthen its position as a building material. By using state-of-the-art techniques such as confocal microscopy and X-ray computed tomography, combined with advanced processing and simulation tools, fundamental insight can be acquired in the wood decay processes.
From in vitro to in silico model: An engineering approach towards design of oil-in-water-based food products with tailored lipid digestion KU Leuven
The digestion of lipids in the human body has several health and nutritional implications. On the one side, a balanced lipid intake provides energy and essential fatty acids. On the other side, lipid overconsumption increases the risk of developing metabolic related diseases such as obesity, diabetes or cardiovascular diseases. In addition, lipid-based products could be employed as delivery systems for lipophilic functional compounds or as ...
Unraveling the role of mechanical cross-talk in the bone-cartilage unit in degenerative joint disease: an in silico multi-scale adaptive modeling approach KU Leuven
Osteoarthritis (OA) is a disease of the whole joint, with a progressive deterioration of cartilage and subchondral bone. Altered mechanical loading is widely accepted, but poorly understood as a driver of OA. Bone and cartilage are mechano-adaptive tissues. It has been assumed that changes in structural and material properties in either tissue caused by altered load distribution, drive mechano-adaptive response adaptations in the other ...
Development, characterization and validation of an in vitro/in silico platform to predict transfer of medicines to human breast milk along with neonatal systemic exposure to maternal medication. KU Leuven
Breastfeeding has been shown to have short- and long-term benefits regarding chronic diseases, cognitive deficits, infant morbidity and mortality. However, breastfeeding adherence in the EU is low. One of the factors leading to the decision not to breastfeed is the lack of safety information for medicines. It is currently impossible to make evidence-based decisions on the use of maternal medication during breastfeeding. Women are counselled ...
Development and use of an integrated in silico – in vitro mesofluidics system for tissue engineering KU Leuven
Tissue Engineering (TE) refers to the branch of medicine that aims to replace or regenerate functional tissue or organs using man-made living implants. As the field is moving towards more complex TE constructs with sophisticated functionalities, there is a lack of dedicated in vitro devices that allow testing the response of the complex construct as a whole, prior to implantation. Additionally, the knowledge accumulated from mechanistic and ...
The role of adipose tissue in arrhythmogenesis: an in silico study KU Leuven
The most common sustained cardiac arrhythmia is atrial fibrillation (AF), affecting approximately 1.5 % of the population [Lip G. et al. 2007]. AF is a progressive disease becoming more prevalent with increasing age and results in increased mortality, morbidity and impaired quality of life [Thrall G. et al. 2006].
AF is associated with important structural, electrical and mechanical (both passive and contractile) remodeling. The disease ...
Improved clearance prediction using ex vivo and new in silico tools to bridge the in vitro to in vivo extrapolation (IVIVE) gap KU Leuven
Despite the implementation of new technologies and approaches in drug discovery over the last years, 90% of drug candidates fail in clinical trials due to insufficient efficacy, toxicity or poor pharmacokinetics (PK) properties. To reduce this attrition rate due to PK, an accurate prediction of (hepatic) clearance (CL(H)), which determines drug exposure and dose prediction, at an early stage is indispensable. Although progress in the field ...