Projects
A time- and dose-limited indication for azithromycin therapy in patients with COPD KU Leuven
Chronic obstructive pulmonary disease (COPD), the 3rd leading cause of death worldwide, is a chronic inflammatory disease of the airways characterized by recurrent infectious exacerbations accelerating disease progression. Azithromycin, an off-patent antibiotic possessing anti-inflammatory properties in addition to antimicrobial effects, holds much promise for patients who are at an increased exacerbation risk. Lacking any profitability for ...
Fibrosis diathesis as indication and possible mechanism of joint stiffness KU Leuven
Dupuytren's disease is a condition where cords and nodules are formed in the hand, causing contractures of the fingers. However, this condition can also occur in the feet and the penis and even in the hand there are big differences in the extent and severity of the disease. The general condition to form this kind of stiff tissue is named "fibrosis diathesis". We believe that this can be an explanation for certain problems of joint stiffness, ...
Towards a goal-oriented approach for medication review in older adults: optimization and evaluation of the RESPECT-tool as a means to elicit and integrate personal goals into medication decision-making KU Leuven
Two years ago, we developed the RESPECT-tool. The RESPECT-tool is an instrument that helps healthcare professionals and patients to explore what really matters to patients. It also supports patients in formulating personal life and health goals and helps healthcare professionals to take these personal goals into account when making decisions about the patient’s medication.
With this project, we want to figure out how the RESPECT-tool can ...
Using ‘real-world’ data to gain knowledge on medication safety during pregnancy: towards a ‘fit-for-purpose’ registration system on maternal medication use and mother-infant outcomes (BELpREG). KU Leuven
SelfMADIP: The effectiveness of an in-hospital medication Self-Management intervention on medication Adherence after DIscharge in patients with Polypharmacy. University of Antwerp
Using ‘real world’ data to enhance medication safety during pregnancy: towards a ‘fit-for-purpose’ registration system on maternal medication use and mother-infant outcomes (BELpREG) KU Leuven
Evidence on medication safety in pregnancy is lacking for most products, despite their frequent use. As randomized controlled trials cannot be performed in this population, opportunities of ‘real-world’ data collection for pharmacoepidemiologic research should be fully exploited. In 2021, a prototype of a comprehensive registration system on maternal medication use and mother-infant outcomes (BELpREG) was developed at KU Leuven, allowing data ...
Syndication of European buyout transactions: the determinants of syndication, the structure of the syndicate, and impact on the performance of the acquired target companies. KU Leuven
Low dose, high resolution Ga-68 PET imaging for oncological indications KU Leuven
Positron Emission Tomography (PET) is a medical imaging modality measuring the in vivo processes of cells and molecules using radiotracers. Compared to other medical imaging techniques, PET still suffers from limited spatial resolution and signal-to-noise ratio. One key factor to resolution degradation is the distance the emitted positron travels before annihilating with an electron. This distance is called positron range. Radionuclides ...
Extending the Amalus drug discovery program: validation studies for immuno-oncological and fibrosis indications to increase the IP and investment value Ghent University
In the Amalus drug discovery program (StepStone), we pursue the establishment of a spin-off company to progress cell-selective inhibitors to clinical trials. This ConcepTT project will increase the IP and investment value of the program.
Our inhibitors possess unique features with respect to competition and represent a first-in-class opportunity.
As single agents, our molecules inhibit metastasis in vivo. In the StepStone ...