Projects
the functional characterization of immune cells-astrocyte interactionsduring CNS inflammation KU Leuven
Validation of a small molecule system for a safer treatment of chronic inflammation Ghent University
We developed in-house an experimental glucocorticoid-based molecule. The small molecule we designed exhibits a unique mode of action consisting of validated anti-inflammatory effects combined with a much safer side effect profile in vivo, as established using rodent models. The aim of our proposal is to translate these well-defined pre-track findings to the relevant end-users in practice. For this we will study early ADMET results in dog ...
Highly versatile real-time live cell imaging for infectious disease and inflammation research. University of Antwerp
A nanobody-based anti-inflammatory treatment against Pseudomonas aeruginosa-induced inflammation in chronic lung diseases Ghent University
Chronic lung inflammation by Pseudomonas aeruginosa is an important driver of pathogenesis in patients with cystic fibrosis (CF). The objective of this project is to develop an effective therapy against P. aeruginosa-induced chronic lung inflammation, by targeting bacterial pro-inflammatory mediators expressed in vivo, using nanobodies.
A nanobody-based anti-inflammatory treatment against pathogen-induced chronic lung inflammation Ghent University
Chronic lung inflammation by Pseudomonas aeruginosa is an important driver of pathogenesis in patients with cystic fibrosis (CF), chronic obstructive pulmonary disease, and non-CF bronchiectasis. Therapies directed at the host inflammatory response hold great promise since it is the major process leading to destruction of lung tissue during infection. The objective of this project is to develop an effective therapy against P. ...
Inflammation, self-regulation and weight loss resistance in children and adolescents with obesity Ghent University
Current project will study the role of inflammation in obese adolescents by evaluating: how inflammation affects maladaptive eating via self-regulation, whether maladaptive eating leads to weight gain and increases of inflammation and psychosocial stress, and whether this stress moderates the relationship between self-regulation and maladaptive eating. We will also evaluate whether psychological interventions can enhance self-regulation and ...
Diagnostic value of mCRP as an early systemic chronic inflammation marker: ongoing clinical validation and derisking Hasselt University
Particulate matter in calf stables: impact on airway inflammation and influential environmental factors Ghent University
The detrimental effects of poor ambient air quality, in particular fine dust (particulate matter), on human respiratory health are extensively studied and well known, in contrast to (farm) animals. Agricultural environments, in particular stables, are important sources of organic dust and emissions of other air pollutants like ammonia. In animals poor air quality induces airway inflammation and pneumonia, but the exact contributing factors ...