Projects
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy Ghent University
Autophagy is crucial in the (patho)physiology, including inflammation, infection and cancer. Autophagy functions as a survival mechanism by maintaining viability during periods of stress, and by removing damaged organelles and toxic metabolites, such as protein aggregates or intracellular pathogens. The Atlantis research consortium (AuTophagy in InfLAmmatioN and inflammaTory dISorders) brings together a team of expert investigators from the ...
The Flemish exposome project: towards a comprehensive understanding of the life-course impact of dietary and environmental exposure on chronic low-grade gut inflammation Acronym = FLEXiGUT Hasselt University
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy. University of Antwerp
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basicinsights to experimental therapy. University of Antwerp
The Flemish exposome project: towards a comprehensive understanding of the life-course impact of dietary and environmental exposure on chronic low-grade gut inflammation (FLEXiGUT) Ghent University
The human exposome covers the totality of non-genetic exposures from conception throughout the life course. The Flemish exposome project, FLEXiGUT, combines the unique and complementary expertise in Flanders on dietary- and environment-related human biomarkers and biomonitoring, metabolomics, microbiome research and epidemiology to investigate the complex human exposome. This first large-scale Flemish Exposome study, will make use of ...
The Flemish exposome project: towards a comprehensive understanding of the life-course impact of dietary and environmental exposure on chronic low-grade gut inflammation (FLEXiGUT). University of Antwerp
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy. KU Leuven
In vivo imaging of the colon in small animals: longitudinal assessment of gut inflammation and colorectal cancer Ghent University
Animal models of colitis and colorectal cancer are frequently adopted by different UGent research groups. As in humans, recurrent endoscopic examination of the colon is important for quantitatively and qualitatively scoring these conditions, but also for early detection of malignancies. It allows to reduce animal numbers, take biopsies, gain maximum clinical data, evaluate microscopic changes, and deliver informative images.
Thymic reprogramming: Systemic inflammation changes the cellular output of the thymus from T cells to NK cells and iron-binding myeloid cells Ghent University
IL-12 and IL-18 are synergistically acting cytokines that are involved in the pathology of both viral infection and sepsis. By culturing ex vivo thymic lobes from neonatal mice, I was able to investigate the cells exiting the thymus following IL-12 and IL-18 stimulation. Surprisingly, this cytokine combination led to the exit of a massive amount of NK cells and myeloid cells into the supernatant of the organ culture. We have been able to ...