ICG-mediated photoporation of the inner limiting membrane to enhance retinal drug delivery after intravitreal injection. Ghent University
Intravitreal injection, injection in the transparent gel of the eyeball, is a commonly applied method in the clinic for delivery of drugs (e.g. antibodies) to the retina. However, larger drugs like gene carriers more than often do no reach the retina. This is very unfortunate since many blinding diseases do require delivery to this target site. It has been shown that the inner limiting membrane (ILM), a thin membrane between the vitreous gel ...