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Augmented Renal Clearance in the Critically Ill: How to Assess Kidney Function (July/August) KU Leuven
BACKGROUND:Augmented renal clearance in critically ill patients can result in underdosing of life-saving drugs, potentially leading to therapeutic failure. To detect this phenomenon, correct assessment of the kidney function is essential. Currently, little is known about the validity of mathematical formulas to estimate renal function in this subset of patients.OBJECTIVE:To evaluate the validity of different METHODS: An observational, ...
Augmented Renal Clearance in the Critically Ill: How to Assess Kidney Function (July/August) KU Leuven
BACKGROUND:Augmented renal clearance in critically ill patients can result in underdosing of life-saving drugs, potentially leading to therapeutic failure. To detect this phenomenon, correct assessment of the kidney function is essential. Currently, little is known about the validity of mathematical formulas to estimate renal function in this subset of patients.OBJECTIVE:To evaluate the validity of different METHODS: An observational, ...
The impact of using estimated GFR versus creatinine clearance on the evaluation of recovery from acute kidney injury in the ICU KU Leuven
To quantify the error in evaluating recovery from acute kidney injury (AKI) with estimated GFR (eGFR) in relation to ICU stay.
Comparison of Plasma Clearance With Early-Compartment Correction Equations and Urinary Clearance in High GFR Ranges KU Leuven
INTRODUCTION: Glomerular filtration rate (GFR) is measured from the late plasma disappearance curve of an exogenous tracer, after correction for the early decay-corresponding to the distribution of the tracer-using various equations. These equations display the highest discrepancies in the GFR range above 90 ml/min per 1.73 m2, and their respective performances against a reference, urinary GFR measurement are unclear. METHODS: In patients with ...
Risk factors of augmented renal clearance in critically ill children using iohexol clearance for renal function assessment Ghent University
Objectives: Augmented renal clearance (ARC) of hydrophilic drugs such as antimicrobials and heparins is frequent in PICU patients and warrants adjustment of standard dosing regimens to prevent therapeutic failure. Knowledge of patient-, disease- and therapy-related factors associated with ARC, would allow to predict before the start of treatment, which patients would benefit from higher drug doses. We aimed to identify predictors of ARC in ...
The development of a juvenile porcine augmented renal clearance model through continuous infusion of lipopolysaccharides : an exploratory study Ghent University
Augmented renal clearance in pediatric intensive care : are we undertreating our sickest patients? Ghent University
Many critically ill patients display a supraphysiological renal function with enhanced renal perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal clearance (ARC) may result in enhanced drug elimination through renal excretion mechanisms. Augmented renal clearance seems to be triggered by systemic inflammation and therapeutic interventions in intensive care. There is growing evidence that ARC is not restricted to ...