Linking extracellular matrix defects and chronic pain: the Ehlers-Danlos syndrome as a disease model Ghent University
Chronic pain is one of the most common, yet poorly studied, complaints in patients suffering from Ehlers-Danlos Syndrome (EDS). This heterogeneous group of heritable connective tissue disorders is characterized by skin hyperextensibility and fragility, joint hypermobility and generalized connective tissue fragility and is caused by defects in a variety of extracellular matrix (ECM) molecules. Chronic pain is a major source of disability and ...