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Timing of Cardiac Resynchronization Therapy Following Stable Medical Therapy in Patients With Heart Failure Hasselt University

Wilfried MULLENS
Background Guidelines' recommendations for cardiac resynchronization therapy (CRT) implantation in selected patients with heart failure (HF) exist. However, data on the best timing for CRT implantation after the achievement of stable medical therapy (SMT) and its association with outcomes are currently lacking. Objectives The aim of this study was to investigate the timing of CRT implantation after the achievement of SMT, associated patient ...

Cardiac resynchronization therapy for enabling guideline-directed medical therapy optimization in heart failure Hasselt University

Wilfried MULLENS
AimsWe aimed to assess whether cardiac resynchronization therapy (CRT) might serve as an enabler for guideline-directed medical therapy (GDMT) optimization. Methods and results Patients with heart failure with reduced ejection fraction (HFrEF) enrolled in the Swedish Heart Failure Registry between January 2009 and August 2022 were considered. Patients receiving a CRT close to the index registration were the cases, whereas controls had not ...

Cardiac contractility modulation treatment in patients with symptomatic heart failure despite optimal medical therapy and cardiac resynchronization therapy (CRT) KU Leuven

Juergen Kuschyk, Herbert Naegele, Karl Heinz-Kuck, Christian Butter, Thomas Lawo, Dietmar Wietholt, Susanne Roeger, David Gutterman, Daniel Burkhoff, Benny Rousso, et al.
BACKGROUND: A significant proportion of patients receiving CRT are non-responders. We evaluated the efficacy of Cardiac Contractility Modulation in subjects with reduced LVEF who, despite cardiac resynchronization therapy (CRT), continued to experience clinically significant symptoms. METHODS: This was a multi-center, open label, treatment-only, feasibility study of 17 CRT non-responders who received CCM therapy. Changes in NYHA class, ejection ...

Benefits of Empiric Nutritional and Medical Therapy for Semen Parameters and Pregnancy and Live Birth Rates in Couples with Idiopathic Infertility Vrije Universiteit Brussel

Muhammad Imran Omar, Raj Prasenjit Pal, Brian D Kelly, Harman Maxim Bruins, Yuhong Yuan, Thorsten Diemer, Csilla Krausz, Herman Tournaye, Zsolt Kopa, Andreas Jungwirth, et al.

CONTEXT: Empiric use of medical and nutritional supplements to improve semen parameters and pregnancy rates in couples with idiopathic infertility has reached global proportions, although the evidence base for their use in this setting is controversial.

OBJECTIVE: We systematically reviewed evidence comparing the benefits of nutritional and medical therapy on pregnancy rates and semen parameters in men with idiopathic infertility.

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Patient profiling in heart failure for tailoring medical therapy. A consensus document of the Heart Failure Association of the European Society of Cardiology Hasselt University

Wilfried MULLENS
Despite guideline recommendations and available evidence, implementation of treatment in heart failure (HF) is poor. The majority of patients are not prescribed drugs at target doses that have been proven to positively impact morbidity and mortality. Among others, tolerability issues related to low blood pressure, heart rate, impaired renal function or hyperkalaemia are responsible. Chronic kidney disease plays an important role as it affects up ...

Catheter Ablation versus Medical Therapy of Atrial Fibrillation in Patients with Heart Failure: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials Vrije Universiteit Brussel

Michele Magnocavallo, Antonio Parlavecchio, Giampolo Vetta, Carola Gianni, Marco Polselli, Francesco De Vuono, Luigi Pannone, Sanghamitra Mohanty, Filippo Maria Cauti, Rodolfo Caminiti, et al.
Background: Atrial fibrillation (AF) and heart failure (HF) often coexist and synergistically contribute to an increased risk of hospitalization, stroke, and mortality. Objective: To compare the efficacy of catheter ablation (CA) versus medical therapy (MT) in HF patients with AF. Methods: Electronic databases were queried for randomized controlled trials (RCTs) of CA versus MT of AF in patients with HF. Risk ratios (RRs), mean differences ...

Catheter Ablation versus Medical Therapy of Atrial Fibrillation in Patients with Heart Failure: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials Vrije Universiteit Brussel

Michele Magnocavallo, Antonio Parlavecchio, Giampolo Vetta, Carola Gianni, Marco Polselli, Francesco De Vuono, Luigi Pannone, Sanghamitra Mohanty, Filippo Maria Cauti, Rodolfo Caminiti, et al.
Background: Atrial fibrillation (AF) and heart failure (HF) often coexist and synergistically contribute to an increased risk of hospitalization, stroke, and mortality. Objective: To compare the efficacy of catheter ablation (CA) versus medical therapy (MT) in HF patients with AF. Methods: Electronic databases were queried for randomized controlled trials (RCTs) of CA versus MT of AF in patients with HF. Risk ratios (RRs), mean differences ...

Medical physics aspects of the synchrotron radiation therapies: microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT) Ghent University

Elke Bräuer-Krisch, Jean-François Adam, Enver Alagoz, Stefan Bartzsch, Jeff Crosbie, Carlos De Wagter, Andrew Dipuglia, Mattia Donzelli, Simon Doran, Pauline Fournier, et al.
Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy (MRT) are both novel approaches to treat brain tumor and potentially other tumors using synchrotron radiation. Although the techniques differ by their principles, SSRT and MRT share certain common aspects with the possibility of combining their advantages in the future. For MRT, the technique uses highly collimated, quasi-parallel arrays of X-ray microbeams between 50 ...

Novel mechanisms and approaches in the medical therapy of solid cancers Vrije Universiteit Brussel

Gil Awada, Hampig Raphael Kourie, Ahmad Hussein Awada

Major advances in cancer research in the last two decades have provided us with a better understanding of the dynamics of the cancer cell and its microenvironment. This has consequently led to the development of new therapies and treatment strategies either targeting the cancer cell or the tumor microenvironment. In this review we will discuss the major existing and promising future treatment approaches in medical oncology. Therapies ...